Tissue Uptake, Distribution, and Healing Response After Delivery of Paclitaxel via Second-Generation Iopromide-Based Balloon Coating
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چکیده
منابع مشابه
Tissue-specific gene delivery via nanoparticle coating.
The use of biomaterials for gene delivery can potentially avoid many of the safety concerns with viral gene delivery. However, the efficacy of polymeric gene delivery methods is low, particularly in vivo. One significant concern is that the interior and exterior composition of polymeric gene delivery nanoparticles are often coupled, with a single polymer backbone governing all functions from bi...
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BACKGROUND Drug-eluting balloons (DEB) may be promising technology for treating atherosclerotic arterial disease. In fact, several DEBs have been clinically available for the treatment of coronary in-stent restenosis (ISR), de novo coronary lesions, and peripheral artery disease. OBJECTIVE We sought to elucidate the mechanism of action and in vivo safety and efficacy of a novel iopromide-base...
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نصب منابع پراکنده در سیستم های توزیع و فوق توزیع علاوه بر مزیت های فراوان، مشکلاتی را هم به همراه دارد. یکی از این مشکلات تأثیر این منابع روی اندازه جریان های اتصال کوتاه است. به طور معمول از حفاظت های مبتنی بر اصل جریان زیاد در سیستم های توزیع و فوق توزیع استفاده می شود. از مهمترین طرح های حفاظتی استفاده شده در فیدرهای توزیع، حفاظت فیوز- ریکلوزر است. همچنین از طرح های حفاظتی جریان زیاد جهتی در...
Biological effect on drug distribution and vascular healing via paclitaxel‐coated balloon technology in drug eluting stent restenosis swine model
OBJECTIVES To evaluate the biological effect of a paclitaxel-coated balloon (PCB) technology on vascular drug distribution and healing in drug eluting stent restenosis (DES-ISR) swine model. BACKGROUND The mechanism of action and healing response via PCB technology in DES-ISR is not completely understood. METHODS A total of 27 bare metal stents were implanted in coronary arteries and 30 day...
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BACKGROUND The efficacy of paclitaxel-coated balloons (PCB) for restenosis prevention has been demonstrated in humans. However, the mechanism of action for sustained drug retention and biological efficacy following single-time drug delivery is still unknown. METHODS AND RESULTS The pharmacokinetic profile and differences in drug concentration (vessel surface vs arterial wall) of two different...
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ژورنال
عنوان ژورنال: JACC: Cardiovascular Interventions
سال: 2013
ISSN: 1936-8798
DOI: 10.1016/j.jcin.2013.04.013